My answer is no. Here's why:
Taking a look at the equation for the coefficient of lift, one can see that the biggest controlling factor we as pilots have over the overall lift on an airplane is what speed we opt to fly at ("s" squared). Since the surface area of a open window is not large enough to produce lift, and any drag would be negligible as opposed to any larger surface producing a known amount of parasite drag already accounted for when the aircraft is in a Vso configuration, other than the noise, you wouldn't notice any difference.
However, if someone opened a door, then the change in performance would be immediately noticeable since you are changing the surface area of the aircraft exposed to the relative wind. You would have to make a much larger control surface and speed correction to account for your newly found parasite drag.
Wow....college did teach me something.